P-75: The Association of Antiphospholipid Syndrome and Recurrent Miscarriages

a:4:{s:10:"Background";s:364:"Antiphospholipid syndrome is a coagulation disorder that causes recurrent miscarriages and fetal deaths. In the present review we summarize current knowledge about Antiphospholipid syndrome that associated with recurrent miscarriages. In addition, on the basis of these comprehensive data, possible pathophysiologic mechanisms of this disorder are discussed.";s:19:"MaterialsAndMethods";s:223:"We searched PubMed using keywords such as “Antiphospholipid Syndrome” and “Recurrent Miscarriages” for articles with significantly high citation that published from 2005 to 2014 and totally 23 articles were used.";s:7:"Results";s:770:"Sixty percent of recurrent spontaneous abortions are unexplained. Antiphospholipid (Hughes) syndrome (APS) is a multisystem disease with the predominant features of venous and arterial thrombosis, recurrent pregnancy loss, fetal death and the presence of antiphospholipid antibodies. Many epidemiological studies focus on antiphospholipid syndrome as a cause of recurrent spontaneous abortion. Researchers have found that having antiphospholipid syndrome can increase women's chances of recurrent miscarriages. They believe that antiphospholipid syndrome causes blood clots to block the blood supply to the placenta. Others believe that having antiphospholipid syndrome may interfere with the fertilized egg’s ability to implant in the lining of the uterus.";s:10:"Conclusion";s:546:"There is accumulating evidence that recurrent miscarriages are associated with APS. Also, many studies demonstrate that thrombosis is observed frequently in the placentas of patients with antiphospholipid syndrome. However, published data showed no correlation between the severity of the disease (the number of previous miscarriages) and the prevalence of antiphospholipid antibodies and that these antibodies were also present in normal women. This review explains that women with APS are at increased risk of Recurrent pregnancy loss.";}